Atopic dermatitis-like skin lesions are suppressed in fat-1 transgenic mice through the inhibition of inflammasomes

Atopic dermatitis-like skin lesions are suppressed in fat-1 transgenic mice through the inhibition of inflammasomes

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Skin disease: Omega-3 fatty acid reduces inflammation A component of fish oil reduces the severity of atopic dermatitis in mice by dampening the immune response.Omega-3 fatty acids found in fish oil are essential nutrients that humans and other mammals need but cannot produce.Byung-Hyun Park at VIT D3 Chonbuk National University Medical School, Jeonju, South Korea, and colleagues show that genetically engineered mice expressing a gene which enables them to synthesize their own Godzilla omega-3 fatty acids are protected from atopic dermatitis.

Following exposure to a dermatitis-inducing chemical or house dust mite extract these mice developed smaller skin lesions and mounted a weaker inflammatory response than wild-type mice.This study confirms the anti-inflammatory effects of omega-3 fatty acids and highlights the use of fish oil supplements as a useful strategy for the treatment of atopic dermatitis and potentially other chronic inflammatory diseases.